pranay.vure

Profile
Pranay

Hello, Pranay here!

I'm a _

Incoming Bioengineering PhD Student @ UPenn. Current Senior @ Duke University majoring in Biomedical Engineering with a focus on molecular and cellular engineering. Experienced in integrating deep learning and generative AI with protein design. Feel free to reach out!!

Experiences
Stealth

ML Engineer

Stealth

Summer 2024 - Present

Building at the intersection of AI and Biotech.

Programmable Biology Group

ML Researcher

Programmable Biology Group

Summer 2023 - Present

Built generative AI & deep learning-based models and platforms for protein design under Dr. Pranam Chatterjee.

Medtronic

Data Science/R&D Intern

Medtronic

Summer 2024

Quantified sympathetic control of renal vasculature and developed indicators for renal denervation treatment efficacy.

Medtronic

Manufacturing Engineering Intern

Medtronic

Summer 2023

Optimized NT-oxygenation system manufacturing, reducing production inefficiencies through data-driven analysis and solution implementation.

Duke Human Vaccine Institute

Immune Engineering Researcher

Duke Human Vaccine Institute

Fall 2021 - Summer 2023

Built and validated epitope-scaffold models to elicit the production of broadly protective coronavirus antibodies under Dr. Mihai Azoitei.

Publications

Oct. 2024

PepDoRA: A Unified Peptide Language Model via Weight-Decomposed Low-Rank Adaptation
- Preprint
Wang, L.†, Pulugurta. R.†, Vure, P†, Pal, A., Zhang, Y., Chatterjee, P. (†equal contribution)
Deep LearningDrug Discovery

Jun. 2024

FusOn-pLM: A Fusion Oncoprotein-Specific Language Model via Focused Probabilistic Masking
- Research Article
Vincoff, S., Kholina, K., Goel, S., Pulugurta, R., Vure, P., Chatterjee, P.
OncologyMachine Learning

Mar. 2024

AMP-Diffusion: Integrating Latent Diffusion with Protein Language Models for Antimicrobial Peptide Generation
- Preprint
Chen, T., Vure, P., Pulugurta, R., Chatterjee, P.
Generative AIProtein Design

Oct. 2023

PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling
- Research Article
Chen, T., Pertsemlidis, S., Watson, R., Kavirayuni, V.S, Hsu, A., Vure, P., Pulugurta, R., Vincoff, S., Hong, L., Wang, T., Yudistyra, V., Haarer, E., Zhao, L., Chatterjee, P.
Drug DesignMachine Learning

Jun. 2023

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling
- Research Article
Bhat, S., Palepu, K. et al., Vure, P., Chatterjee, P.
Protein DesignMachine Learning

Nov. 2023

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes
- Research Article
Kapingidza, B. et al., Vure, P., Azoitei, M.L.
ImmunologyProtein Design

Projects
2024

ALDH2 Delivery via AAV

Transient Delivery of ALDH2 via Adeno-Associated Virus to Mitigate Alcohol-Induced Toxicity

Vure, P., Chen, R., Koneru, H., Lashkari, V., Tran, M., Gatongi, M., Kim, C.

2024

NCAM1 Specific Binders

Design of NCAM1 Specific Binders Towards Neuroendocrine Prostate Cancer Therapy

Kavirayuni, V.S., Vure, P., Yerrabelli, R., Goodingham, E.P., Hong, L., Tran, M., Gatongi, M., Chatterjee, P.

2024

DISTCLIP

DISTCLIP: Advancing Protein-Protein Interaction Predictions Through Contrastive Learning of Distograms

Vure, P., Hsu, A., Pulugurta, R., et al., Chatterjee, P.

2024

Anti-CRISPRTune

Anti-CRISPRTune: Fine-Tuning ProtGPT2 and ESM-2 for the Generative Design of Anti-CRISPR Proteins

Vure, P., et al., Chatterjee, P.

2023

Glucose-Insulin Dynamics

Modeling Effects of Humalog and Ozempic on Glucose and Insulin Dynamics in Healthy & Type 2 Diabetes Patients

D'Cunha, R., Vure, P., Docters, S., Baldwin, B., Le, P.

Blog
March 26, 2025
10 min read

Bioengineering Primer: Fighting Viruses That Change Their Face

An introduction to bioengineering and a glimpse into my research on designing proteins to combat coronavirus variants.

When I tell people I'm majoring in bioengineering, conversations often end quickly with a polite nod or a question about prosthetics, highlighting how unfamiliar most people are with the extent of the field. This article introduces the field of bioengineering and explores my research on designing proteins that can help fight coronaviruses by targeting parts that don't change.
Read on Substack
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